Park JK, Im M, Seo YJ, Lee JH
Department of Dermatology, College of Medicine, Chungnam National University, Deajon, Korea

Androgenetic alopecia (AGA) occurs as a result of progressive miniaturization of scalp hair in genetically predisposed individuals. Several effective treatments for AGA are well known. However, there is a paucity of literature about the influences of such treatments on the frontal hair line. Hence, this study was designed to assess the effectiveness of oral finasteride and/or topical minoxidil on the frontal hair line. The assessment was made on 80 male patients with AGA of grades II to V, based on the Hamilton scale after six months of treatment. The patients were divided into three groups. Group 1 received 1 mg of oral finasteride daily. Group 2 exclusively used 5% minoxidil solution twice daily. Group 3 received 1 mg of finasteride daily in combination with a topical application of 5% minoxidil solution. We measured the length from the mid-pupillary line to three points of the FHL; midpoint of the forehead, right and left temporal recession, respectively. An improvement of the FHL was observed in all of three groups. There was a tendency for patients taking only finasteride to show an overall improvement in the FHL, while patients applying only minoxidil solution showed an improvement mainly in both temporal recession lines. Comparing the three groups, Group 3 showed the best result, followed by Group 1, and finally Group 2. In conclusion, we found that the application of finasteride and/or minoxidil tended to influence the frontal hair line to different extents and in varying patterns.