L10 BIOLOGICALS AND ALOPECIA AREATA: WHAT CAN WE LEARN FROM THEM?
Hoffmann R
Dermaticum - Practice for Dermatology, Freiburg i. B., Germany

Alopecia areata (AA) is a suspected hair follicle specific autoimmune disease. Recent research using the C3H/HeJ mouse model have shown that immune molecules such as CD4, CD8, CD44v10, FAS, FAS-ligand, IL-10, IFN-gamma, IL-2 and others play an important role during different steps of the disease. Many immunologic events in AA share similarities with other autoimmune disease where new therapeutic modalities such as biologicals are at the horizon. It is therefore tempting to speculate that those new therapies may have a curative effect in AA as well. The presentation will therefore summarize recent aspects of AA immunology and may give a future outlook what types of biologicals may be beneficial for AA.